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Multisystem physiologic impairments and changes in gait speed of older adults.
Wednesday,2015-03-04 14:06 America/Los_Angeles — zdrager
| Title | Multisystem physiologic impairments and changes in gait speed of older adults. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Rosso, AL, Sanders, JL, Arnold, AM, Boudreau, RM, Hirsch, CH, Carlson, MC, Rosano, C, Kritchevsky, SB, Newman, AB |
| Journal | J Gerontol A Biol Sci Med Sci |
| Volume | 70 |
| Issue | 3 |
| Pagination | 319-24 |
| Date Published | 2015 Mar |
| ISSN | 1758-535X |
| Keywords | Age Factors, Aged, Aged, 80 and over, Brain, Cardiovascular Physiological Phenomena, Cohort Studies, Female, Gait, Geriatric Assessment, Glucose, Health Status Indicators, Humans, Kidney, Lung, Male, Sensitivity and Specificity, Time Factors |
| Abstract | <p><b>BACKGROUND: </b>Slowed gait is an important health indicator in older adults but a single identifiable cause is often lacking. We assessed whether a summary index measuring impairments across multiple physiologic systems was associated with slowed gait in older individuals.</p><p><b>METHODS: </b>Data from the Cardiovascular Health Study (n = 3,010) were used to assess associations between baseline physiologic index (measuring vasculature, brain, kidneys, lungs, and glucose metabolism; range 0-10 with 0-2 points/system and lower score indicating higher function) and annual gait speed (m/s) over 6 years. Participants with complete data on the physiologic index and at least two gait speed measures were included. Mean gait speed and 95% confidence intervals (CI) by category of index were calculated using mixed effects models.</p><p><b>RESULTS: </b>Those with scores of three or higher on the index had significantly slower gait speed at baseline compared to those with scores of 0-2 (7-10: mean speed = 0.83 m/s, 95% CI: 0.80, 0.84; 0-2: mean speed = 1.01 m/s, 95% CI: 0.99, 1.03). Those with higher indices also had faster decline in gait speed compared to those with lower scores after adjustment for demographic and health characteristics (7-10: change in speed = -0.020 m/s/year, 95% CI: -0.024, -0.016; 0-2: change in speed= -0.010 m/s/year, 95% CI: -0.014, -0.006).</p><p><b>CONCLUSIONS: </b>Greater impairment across five organ systems was associated with slower gait speed and greater declines in gait speed over 6 years. Impairments accumulated over multiple physiologic systems may make older adults more vulnerable to slow gait speed.</p> |
| DOI | 10.1093/gerona/glu176 |
| Alternate Journal | J. Gerontol. A Biol. Sci. Med. Sci. |
| PubMed ID | 25380599 |
| PubMed Central ID | PMC4351395 |
| Grant List | P30 AG024827 / AG / NIA NIH HHS / United States N01HC85080 / HC / NHLBI NIH HHS / United States N01HC85081 / HC / NHLBI NIH HHS / United States N01HC85079 / HC / NHLBI NIH HHS / United States T32 AG000181 / AG / NIA NIH HHS / United States N01HC85086 / HC / NHLBI NIH HHS / United States N01HC85082 / HC / NHLBI NIH HHS / United States HHSN268200800007C / / PHS HHS / United States HHSN268201200036C / / PHS HHS / United States HL080295 / HL / NHLBI NIH HHS / United States N01HC85083 / HC / NHLBI NIH HHS / United States R01 AG023629 / AG / NIA NIH HHS / United States AG023629 / AG / NIA NIH HHS / United States T32-AG-000181 / AG / NIA NIH HHS / United States N01 HC55222 / HC / NHLBI NIH HHS / United States |